Pcb reverse engineering is also known as pcb copy, pcb cloning or pcb duplication. This process is required to receive fda approval for commercialization. Another concern in the electronics industry is ic piracy using re rahman et al. Reverse engineering of ayurvedic lipid based formulation. Having this experience give us a unique position to assist our customers in preparation for manufacturing. Reverse engineering of printed circuit boards stacks are the. Topic of seminar seminar on reverse engineering of. Pharmaceutical deformulation of innovator is the technical term for reverse engineering the separate components that make up the drug composition. In vitro bioequivalence data for a topical product. How can one do reverse formulations of pharmaceutical. Reverse engineering of a formulation can be done using public domain information about the composition of a drug product, and applying knowledge and experience of formulation science to develop an approximation to the quantitative formula and likely manufacturing process. Deformulation or reverse engineering of a chemical formulation provides specific information about the composition of formulated products and how these components interact.
Reverse engineering typical process generic reverse engineering process piece parts simple determine need for re purchase order for reverse engineering service generate interface plan evaluate the part generate technical data package tdp perform interim suitability for use evaluation purchase order for manufactured part manufacture. Reverse engineering a printed circuit board pcb is useful for. For an overthe counter cold and flu remedy these differences may be trivial but for formulations requiring submission to the fda these differences would be critical therefore the ability to identify and characterise different components within a formulation can be critical when reverse engineering a product. Understanding the art of reverse engineering helps a company to decide its intellectual properties should be protected by industry secrets, patents, orand copy right. The role of reverse engineering in the development of generic formulations article in pharmaceutical technology 298.
Reverse engineering of ayurvedic lipid based formulation, ghrita by combined column chromatography, normal and reverse phase hptlc analysis selvakumar duraipandi, vijaya selvakumar and ng yun er abstract background. Deformulation and reverse engineering smithers provides a comprehensive formulation analytical service to a wide range of industries, companies and individuals. Thisworkislicensedunderthecreativecommonsattributionnoncommercial. Hardware trust and assurance through reverse engineering. A benchmark for methods in reverse engineering and model. Case studies of reverse engineering a solid and liquid pharmaceutical formulation 3. In this context, reverse engineering of the innovator products formulation is a scientifically sound and costeffective strategy for accelerating generic product development. You can use it either to study the design process, or as an initial step in the redesign.
The reverse engineering re of electronic chips and systems can be used with honest and dishonest in. The seminar gave an insight the strategiesand various into analytical techniques used in deformulation of both solid and liquid pharmaceutical formulations. It can be said that the previous preparation work is done for it. Langdon and westley weimer y university college london, crest centre, uk y university of virginia, virginia, usa abstract this paper overviews the application of search. Reverse engineering of a pharmaceutical formulation. At this place, reverse engineering comes into play. The reason is that being able to introduce a product at the market before having it industrialized and therefore before. I have worked on multiple reverse engineering formulation projects with the goal of developing a generic drug product, so i felt that i should throw my two cents in on this one. Nonetheless, it is not required in preparation of a penetration test. A benchmark for methods in reverse engineering and model discrimination. In other word reverse engineering is a systematic a pproach for analyzing the design of existing devices or systems 14. Here, we provide an example case study for a powder formulation. Adhesive formulations analysis is key to a wide range of industries from packaging to the electronics industries in regard to integrity, mixing and consistency and ensuring more control over a wide variety of potential future issues. Reverse engineering integrated circuits using finite state.
The following are some of the topics that shall be deliberated in the seminar. This can be as simple as determining the major component, or as detailed as looking for additives that may. Probe stations are highly precise manual probe units for wafers and. The society of manufacturing engineers sme states that the practice of reverse engineering starting with a finished product or process and. This work was based on an acyclovir ointment of commercial name zovirax 5%. Reverse engineering has been used to produce many mechanical parts, such as seals, orings, bolts and nuts, gaskets, and engine parts, and is widely used in many industries tut, 2010.
Production critical environments solid dose manufacturing liquid dose manufacturing. In this case the acquisition time was 10 seconds for each particle and spectra from a few thousand particles from each sample were gathered in an overnight analysis. Deformulation reverse engineering lab eag laboratories. Alexandre has presented at several conferences, including hitb kuala lumpur 2009 and recon montreal 2010 and 2011.
Genetic programming for reverse engineering invited paper. Pdf reverse engineering re of electronic chips and systems can be used with. Im also in the process of starting a blog to educate interested folk. Topics dealing with role of reverse engineering in development of generic prothe ducts. Reverse engineering of oral solid and liquid formulations on 11th was organized august, 2017. Reverse engineering integrated circuits using finite state machine analysis abstract due to the lack of a secure supply chain, it is not possible to fully trust the integrity of electronic devices. Deformulation or reverse engineering of a chemical formulation provides specific information about the composition of formulated products and. Zovirax 5% ointment, consists of 5% ww acyclovir and 95% ww of a polyethylene glycol base reference product. Role of reverse engineering in development of generic products 2. Elias bachaalany has been a computer programmer, reverse engineer, freelance technical writer, and an occasional reverse engineering trainer for the past 14. We performed a series of experiments using both inexpensive homebased solutions and.
Get more pharma manufacturing insight with our free newsletter sign me up. Genetic programming for reverse engineering mark harman, william b. Reverse engineering, or deformulation, of chemical formulations, materials and products delivered by experienced analytical industry experts. From a practical perspective, the chances of developing a bioequivalent product can be significantly increased by extending the concept of generic product sameness to. Also known as reverse engineering, deformulation is the separation, identification and quantitation of ingredients in a formulation. How to do reverse engineering in design download ebook pdf. Just use the example of manual sanding, when we finish sanding the top layer of. It is a great bookmanual to read and very helpful to understand the arts of. Reverse engineering of oral solid and liquid formulations. Reverse engineering pharmaceutical tablets by semedx and. After receiving so many queries about cosmetics reverse formulation i decided it is time to write about it. Journal of innovations in pharmaceutical and biological. Eag is the industry leader in the deformulation of products and materials.
We offer deformulation analysis of products, this is also referred to as reverse engineering or competitor product analysis. Reverse engineering of a pharmaceutical formulation the morphologi g3id can be used to generate componentspecific particle size and shape data required to aid the reverse engineering of solid oral dose formulations. Deformulation analysis of a product, also known as chemical reverse engineering is the process of analytically breaking down a material or products formulation to separate and determine the specific identity and exact quantity of both its major and minor constituent components. The present work deals with reverse engineering on four rubber formulations.
Information about the material composition of the compounding formulations was obtained by using techniques such as acetone extract, thermogravimetric analysis, energy dispersive x. The role of reverse engineering in the development of. Reverse engineering re is a class of development processes that starts. The key point is that errors can enter the system and processes should be formulated to detect. Reverse engineering of oral solid and liquid formulations within the academic community. Reverse engineering of chemical formulations openclose. Such reverse engineering of tablets can be useful when evaluating a thirdparty pr oduct of unknown formulation to. The article presents information on the components of reverse engineering and its role in the development of generic formulations.
What is pcb reverse engineering how to reverse a pcb fps. Accelerated development of pharmaceutical formulations. Reverse engineering and deformulation of chemical formulations. Ghritas are ayurvedic lipid based preparations in which oil or ghee is boiled with prescribed kasaya. Reverse engineering in design plays a key role in every industry, whether you use reverse engineering to understand how something was designed, to reproduce components for which no documentation exists or to identify the root cause of failures. Antireverse engineering techniques for integrated circuits and electronics. Pdf antireverse engineering techniques for integrated circuits. Beyond reverse engineering white paper introduction the global pharmaceutical industry is an enormous market and generics are forming an increasingly important part of this sector. Mechanical reverse engineering philadelphia university. Reverse engineering has emerged as a diverse field that has found several biologically relevant applications due to recent advances in the field of systems biology, which have yet to become accessible to the general public as is the case with reverse engineered products in other fields. Then youll need to run several hundred to thousand experiments trying to just build up the target active ingredient from cheap, commercial starting materials. Remember how in the early days of modern electronics, many.
Problem formulation and solutions andreas kremling, 1, 5 sophia fischer, 1 kapil gadkar, 2 francis j. You need to figure out precisely determine what the product is made of. Reverse engineering and its applications sciencedirect. Doyle, 2 thomas sauter, 3 eric bullinger, 4 frank allgower, 4 and ernst d. Purpose for this project, a program was written which can automatically reverse engineer a netlist of a one or twolayer printed circuit board pcbs from photos of the board. Reverseengineeringforbeginners dennisyurichev 202015,dennisyurichev. Electrical and electronics engineers, proceedings, ieee wescon, august. Pcb reverseengineering is a skill that requires more than just an.
Reverse engineering re is generally defined as a process of analyzing an object or existing system hardware and software to identify its components and their interrelationships and to. Eags chemists have performed reverse engineering studies for hundreds of pharmaceuticals and medical devices. Journal of innovations in pharmaceutical and biological sciences jipbs. Reverse engineering for software and digital systems federal.
The primary purpose of printed circuit board pcb reverse engineering is to determine electronic system or subsystem functionality by analyzing how components are interconnected. Determination of compounding formulation of cured rubber. Our extensive libraries have references to the majority of standard materials and enable our team to identify most polymer components within a formulation. Pcb solutions gets a lot of calls about reverse engineering. Some people approached me to talk about how to research the formulation of a cosmetic product they really like to use it as a starting platform for a new product.
664 671 833 1110 534 889 1169 1188 137 452 598 1188 761 764 134 610 636 376 46 201 1225 62 1252 471 1140 339 969 374 1098 762 334 1027 1232 1125 828 1294 798 786 177 685 937 588 971